What is The Celltex Difference?
In the rapidly expanding field of regenerative medicine, there are several primary methods of obtaining, isolating and applying stem cells: Bone Marrow Aspirate Concentrate (BMAC), Stromal Vascular Fraction (SVF), and Platelet-Rich Plasma (PRP). Each method has its own advantages and disadvantages, but the Celltex Difference involves the use of autologous Mesenchymal Stem Cells (MSCs) that contain immense therapeutic potential and no risk of bodily rejection. The individual experiences a one-time, minimally invasive fat extraction and receives hundreds of millions of their own pure MSCs.
BMAC is a solution of stem cells and platelets derived from bone marrow. Within this solution are contained mesenchymal, hematopoietic, and endothelial stem cells. Drawn primarily from the iliac crest, the sample is centrifuged and immediately administered back to the patient. Volume and quality of bone marrow is very age- and health situation-dependent, and this invasive procedure must be performed for every treatment.
SVF is obtained from native adipose tissue or during a lipoaspirate procedure. Following the procedure, enzymes are added to digest the fat and release the cells, which include preadipocytes, mesenchymal stem cells, endothelial cells, monocytes/macrophages, T regulatory cells, and white blood cells. Though SVF has vast cell population and multilineage differentiation capacity, the number of cells is limited due to the volume of tissue that can be obtained. Liposuction must be performed for each SVF treatment, and large amounts of adipose tissue are required for adequate treatment.
PRP is plasma from blood that has been enriched for platelets and has reduced concentration of white blood cells. Often prior to application, an activator of the platelets is added (such as thrombin or calcium chloride) to release an array of growth factors and cytokines. PRP therapy requires blood to be drawn from the patient for each treatment, and the administration method is limited to local injections only. Compared to SVC and MSC treatments, the applications are relatively narrow, and the concentrations of growth factors in PRP are varied due to health conditions at the time of blood withdrawal.
The Celltex Difference is based on autologous mesenchymal stem cells (MSCs), which are immune evasive progenitor cells that possess potent immunomodulatory properties and can divide in an undifferentiated state, enabling culture expansion of pure populations for therapeutic application. MSCs can differentiate into cells that can produce an array of tissue types, such as bone, fat, and cartilage. Additionally, MSCs have been shown to modulate both the adaptive and innate immune responses and have the capacity to promote new blood vessel formation. Therapy applications have been promising for multiple conditions, including cardiovascular disease, brain and spinal cord injury, stroke, diabetes, cartilage and bone injury (including arthritis), multiple sclerosis, inflammatory bowel disease, and graft versus host disease, and more.
Celltex’s proprietary technology allows for a one-time fat extraction that provides MSCs, which are then cultured to increase their numbers, proliferate efficiently without differentiation, and remain genetically stable up to more than ten passages. Throughout the process, the cells are strictly monitored under controlled current Good Manufacturing Practices (cGMP) in order to ensure quality.
Celltex Technology Platform
Celltex’s state-of-the-art platform technology involves four key elements:
Separation & Passaged Culture Technology
Cells must first be isolated and separated from the fat tissue. Celltex’s process uses fat tissue as its primary source because of the consistency of the cells in each sample. (Find out more about why we use fat.) Our process involves the careful separation of just the Mesenchymal Stem Cells (MSCs) from a very small fat tissue sample – small enough to be minimally invasive for any donor. The newly separated MSCs undergo our Passaged Culture process that can multiply exponentially the separated cells into millions and millions of identical copies.
After the cells have been separated and cultured, it is imperative that cells can be safely preserved for future use. Celltex’s patented and proprietary banking technology ensures the best conditions for short and long-term storage of stem cells so that they can be used in the future.
Various disease indications are being investigated with research partners around the globe. We are doing what we can to understand the mechanism of how stem cells work to treat diseases and how best to deliver cells to patients.
Quality Control Process
Celltex has a quality assurance and control process that is unsurpassed. We use the best technologies to ensure that cells are being processed properly and that the released cells meet all of our quality standards.